Histone Deacetylase Inhibitors Affect Dendritic Cell Differentiation and Immunogenicity
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چکیده
منابع مشابه
Histone deacetylase inhibitors affect dendritic cell differentiation and immunogenicity.
PURPOSE Histone deacetylases (HDAC) modulate gene transcription and chromatin assembly by modifying histones at the posttranscriptional level. HDAC inhibitors have promising antitumor activity and are presently explored in clinical studies. Cumulating evidence in animal models of immune disorders also suggests immunosuppressive properties for these small molecules, although the underlying mecha...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2007
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-06-2903